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UID:20251026T010240EDT-0072AGber2@132.216.98.100
DTSTAMP:20251026T050240Z
DESCRIPTION:Dr. Peter Cresswell\nEugene Higgins Professor of Immunobiology
 \nInvestigator\, Howard Hughes Medical Institute\nYale University School o
 f Medicine\n \nAntigenic peptides generated in the cytosol are translocate
 d\ninto the endoplasmic reticulum by the ATP-dependent ‘Transporter\nassoc
 iated with Antigen Processing’ (TAP)\, where they bind to newly\nsynthesiz
 ed MHC class I molecules. TAP\, together with the MHC class\nI molecule it
 self\, and calreticulin\, ERp57 and the specialized\nglycoprotein\, tapasi
 n\, form the peptide loading complex\n(PLC).  Tapasin is critical for load
 ing MHC class I molecules\nwith high affinity peptides. It functions withi
 n the PLC as a\ndisulfide-linked\, stable heterodimer with the thiol oxido
 reductase\nERp57\, and this covalent interaction is required to support op
 timal\nPLC activity. The structure of the tapasin/ERp57 dimer revealed the
 \nbasis for the stable dimerization of tapasin and ERp57 and provided\nthe
  first example of a protein disulfide isomerase family member\ninteracting
  with a substrate. Mutational analysis has mapped a\nconserved surface on 
 tapasin that interacts with MHC class I\nmolecules and is critical for the
  peptide loading function of the\ntapasin-ERp57 heterodimer. These results
  illuminate the processes\ninvolved in MHC class I peptide loading.\n
DTSTART:20091019T160000Z
DTEND:20091019T160000Z
LOCATION:McIntyre Medical Building\, CA\, QC\, Montreal\, H3G 1Y6\, 3655 pr
 omenade Sir William Osler
SUMMARY:Archibald Lecture Series:  Dr. Peter Cresswell
URL:/channels/event/archibald-lecture-series-dr-peter-
 cresswell-109840
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