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UID:20250907T160603EDT-6122wZ3vtl@132.216.98.100
DTSTAMP:20250907T200603Z
DESCRIPTION:Abstract:\n\nLiving cells are divided into functional compartme
 nts called organelles. In eukaryotes\, lipid membranes separate organelles
  from the cytoplasm such that each compartment maintains a distinct bioche
 mical composition that is tailored to its function. In contrast\, prokaryo
 tes typically lack internal membranes and instead must use other mechanism
 s to spatially organize the cell. One possible alternative is liquid-liqui
 d phase separation (LLPS)\, which has recently emerged as a novel mechanis
 m for compartmentalization in eukaryotic cells. For example\, the nucleolu
 s assembles by LLPS as soluble components condense from the nucleoplasm to
  form dynamic droplets around ribosomal DNA. We hypothesize that a similar
  process occurs in bacteria to regulate ribosome biogenesis in response to
  nutrient availability. Indeed\, when cells are up-shifted to rich medium\
 , RNA polymerase concentrates into distinct clusters that correlate with r
 ibosomal RNA transcription. We are currently testing whether these cluster
 s represent structural and/or functional homologs of the eukaryotic nucleo
 lus. If so\, then LLPS may serve as a universal organizing principle that 
 extends across the entire tree of life.\n\nBio:\n\nDr. Stephanie Weber is 
 an Assistant Professor of Biology and Associate Member in Physics at McGil
 l University. She received dual Bachelor’s degrees in Biology and Chemistr
 y from Duke University and a PhD in Biochemistry from Stanford University.
 \n\nWorking jointly with Julie Theriot and Andy Spakowitz as a graduate st
 udent\, she characterized the dynamics of chromosomal loci in bacteria and
  discovered that their anomalous motion is governed by the physical proper
 ties of the cytoplasm as well as nonequilibrium ATP-dependent biological a
 ctivity. As a Damon Runyon Postdoctoral Fellow with Cliff Brangwynne at Pr
 inceton University\, Dr. Weber demonstrated that the nucleolus\, a large m
 embraneless organelle\, assembles through phase separation of the nucleopl
 asm and scales with cell size during embryonic development and multicellul
 ar growth.\n
DTSTART:20200121T180000Z
DTEND:20200121T193000Z
LOCATION:Room 10\, Maass Chemistry Building\, CA\, QC\, Montreal\, H3A 0B8\
 , 801 rue Sherbrooke Ouest
SUMMARY:Chemical Society Seminar: Stephanie Weber - No membrane\, no proble
 m: condensing bacterial organelles
URL:/chemistry/channels/event/chemical-society-seminar
 -stephanie-weber-no-membrane-no-problem-condensing-bacterial-organelles-30
 3018
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