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UID:20250910T012316EDT-2748hP2paJ@132.216.98.100
DTSTAMP:20250910T052316Z
DESCRIPTION:Zoom link: https://mcgill.zoom.us/j/88432250653\n\nAbstract:\n
 \nEnzymes are dynamic molecules\, and this flexibility is essential to the
 ir catalytic function. Yet\, computational enzyme design algorithms are ty
 pically performed using a single protein scaffold as design template\, ign
 oring the important contributions of dynamics in enzyme catalysis. For the
  past few years\, my group has developed multistate computational protein 
 design methods that allow proteins to be modelled as structural ensembles 
 that more realistically represent the range of conformations that these mo
 lecules can adopt in solution. Here\, I will show our recent work in the d
 evelopment of ensemble-based computational enzyme design algorithms and th
 eir application in the design of enzyme catalysis\, multisubstrate specifi
 city\, and conformational equilibrium.\n\nBio:\n\nRoberto Chica received h
 is B.Sc. in biochemistry from Université de Montréal in 2001 and his Ph.D.
  from the same institution in 2007 under the mentorship of Joelle Pelletie
 r and Jeffrey Keillor. After working at Caltech as postdoctoral fellow wit
 h Stephen Mayo\, he joined the Department of Chemistry at the University o
 f Ottawa in 2010\, where he is now Full Professor. Since establishing his 
 independent research program\, Dr. Chica has been pushing the boundaries o
 f protein engineering through his pioneering work in the development and e
 xperimental validation of multistate approaches to computational protein d
 esign. In 2019 he was awarded the Melanie O’Neill Young Investigator Award
  in Biological Chemistry from the Canadian Society for Chemistry\, as well
  as the Young Investigator Award of the Biophysical Society of Canada for 
 his advances in protein design. His current research interests include the
  computational design of de novo enzymes and protein-based biosensors.\n
DTSTART:20210413T170000Z
DTEND:20210413T183000Z
SUMMARY:Chemical Society Seminar: Roberto Chica  - Ensemble-based computati
 onal design of enzyme catalysis\, specificity\, and conformational equilib
 rium
URL:/chemistry/channels/event/chemical-society-seminar
 -roberto-chica-ensemble-based-computational-design-enzyme-catalysis-330286
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