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UID:20250906T024421EDT-0086XtCduz@132.216.98.100
DTSTAMP:20250906T064421Z
DESCRIPTION:Abstract:\n\nThe combination of sequential biocatalytic reactio
 ns in non-natural synthetic cascades is a rapidly developing field and lea
 ds to the generation of complex valuable chemicals from simple precursors.
  (for a recent review see Nat Rev Methods Primers 2021\, 1\, 46). As the t
 oolbox of available biocatalysts continues to expand\, so do the options f
 or biocatalytic retrosynthesis of a target molecule\, leading to new route
 s employing enzymatic transformations. To facilitate the design stage\, we
  have established RetroBioCat\, a computer-aided synthesis planning tool f
 or biocatalytic reactions and cascades (Nat Catal 2021\, 4\, 98). The impl
 ementation of such cascade reactions requires careful consideration\, part
 icularly with respect to whether the pathway is constructed in vitro or in
  vivo\, in batch format or in flow (Angew Chem Int Ed 2021\, 60(34)\, 1866
 0). This lecture will showcase several successful de novo cascades and dis
 cuss the relative merits of in vitro\, in vivo or hybrid approaches to bui
 lding biocatalytic cascades.\n\n \n\nBio:\n\nSabine Flitsch is Professor a
 t the School of Chemistry at the University of Manchester. She was educate
 d in Germany\, receiving her Diplom in Chemistry from the WWU Muenster and
  then obtained her DPhil under the supervision of Sir Jack Baldwin at Oxfo
 rd University (UK). After three years as a postdoctoral fellow at MIT (USA
 ) with Professor H.G. Khorana\, she moved back to the UK\, where she has h
 eld academic positions at the Universities of Oxford and Edinburgh\, and m
 oved to Manchester in 2005\, where she currently holds a Chair in Chemical
  Biology. Sabine has served as associate editor of JACS AU since 2019.\n
DTSTART:20221025T170000Z
DTEND:20221025T183000Z
LOCATION:Room 10\, Maass Chemistry Building\, CA\, QC\, Montreal\, H3A 0B8\
 , 801 rue Sherbrooke Ouest
SUMMARY:Chemical Society Seminar:  - Sabine Flitsch-Design and implementati
 on of de novo biosynthetic cascades for organic synthesis
URL:/chemistry/channels/event/chemical-society-seminar
 -sabine-flitsch-design-and-implementation-de-novo-biosynthetic-cascades-34
 0122
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