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UID:20250910T042429EDT-12821H5VmO@132.216.98.100
DTSTAMP:20250910T082429Z
DESCRIPTION:Small molecules that bind to proteins can serve as powerful med
 icines. However\, diseases caused by deficiencies of protein function are 
 generally refractory to this classic approach. Fortunately\, nature has pr
 ovided inspiration for an alternative strategy in the form of small molecu
 les that can autonomously perform higher-order\, protein-like functions in
  the context of living systems. The existence of these natural prototypes 
 suggests that small molecules may possess untapped potential to replace de
 ficient proteins that underlie human diseases\, thereby operating as prost
 heses on the molecular scale. This lecture will describe how recent advanc
 es in synthetic organic chemistry have played a major role in understandin
 g and utilizing these molecules. Specifically\,  analogous to peptide synt
 hesis\, iterative cross-coupling with MIDA boronates has emerged as an inc
 reasingly general and now fully automated way to prepare complex small mol
 ecules with  maximized efficiency and flexibility\, thereby enabling syste
 matic studies of their functions. Collectively\, these advances are transf
 orming molecular prosthetics into a powerful and general strategy for prom
 oting the understanding and betterment of human health.\n\nReferences\n	(1)
  Davis\, S. A.\; Vincent\, B. M.\; Endo\, M. M.\; Whitesell\, L.\; Marchil
 lo\, K.\; Andes\, D. R.\; Lindquist\, S.\; Burke\, M. D. 'Nontoxic\n	Antimi
 crobials that Evade Drug Resistance' Nat. Chem. Bio. 2015\, 11\, 481.\n	(2)
  Li\, J.\; Ballmer\, S. G.\; Gillis\, E. P.\; Fujii\, S.\; Schmidt\, M. J.
 \; Palazzolo\, A. M. E.\; Lehmann\, J. W.\; Morehouse\, G. F.\; Burke\, M.
  D.\n	'Synthesis of Many Different Types of Organic Small Molecules Using O
 ne Automated Process' Science 2015\, 347\, 1221.\n	(3) E.M. Woerly\, J. Roy
 \, M.D. Burke\, Nature Chemistry 2014\, 6\, 484-491.\n	(4) T.M. Anderson\, 
 M.C. Clay\, A.G. Cioffi\, K.A. Diaz\, G.S. Hisao\, M.D. Tuttle\, A.J. Nieu
 wkoop\, G. Comellas\, S. Wang\, B.E. Uno\,\n	E.L. Wildeman\, N. Maryum\, T.
  Gonen\, C.M. Rienstra\, M.D. Burke. Nature Chemical Biology\, 2014\, 10\,
  400-406.\n	(5) Wilcock\, B. C.\; Endo\, M. M.\; Uno\, B. E.\; Burke\, M. D
 . J. Am. Chem. Soc. 2013\, 135\, 8488-849.\n	(6) Wilcock\, B. C.\; Uno\, B.
  E.\; Bromann\, G. L.\; Clark\, M. J.\; Anderson\, T. M.\; Burke\, M. D. N
 ature Chemistry 2012\, 4\, 996.\n	(7) K.C. Gray\, D.S. Palacios\, I. Dailey
 \, M.M. Endo\, B.E. Uno\, B.C. Wilcock\, M.D. Burke. Proc. Natl. Acad. Sci
 . U.S.A. 2012\, 109\,\n	2234.\n	(8) J. Li\, M.D. Burke. J. Am. Chem. Soc. 20
 11\, 133\, 13774.\n	(9) D.S. Palacios\, I. Dailey\, D.M. Siebert\, B.C. Wil
 cock\, M.D. Burke. Proc. Natl. Acad. Sci. U.S.A. 2011\, 108\, 6733.\n	(10) 
 E.M. Woerly\, A.H. Cherney\, E.K. Davis\, M.D. Burke. J. Am. Chem. Soc. 20
 10\, 132\, 6941-6943.\n\n \n
DTSTART:20160119T180000Z
DTEND:20160119T193000Z
LOCATION:Rm 10\, Maass Chemistry Building\, CA\, QC\, Montreal\, H3A 0B8\, 
 801 rue Sherbrooke Ouest
SUMMARY:Sigma-Aldrich Lecture: Dr. Martin Burke - Making Molecular Prosthet
 ics with a Small Molecule Synthesizer
URL:/chemistry/channels/event/sigma-aldrich-lecture-dr
 -martin-burke-making-molecular-prosthetics-small-molecule-synthesizer-2575
 61
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