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DTSTAMP:20250909T081150Z
DESCRIPTION:The Killam Seminar Series presents 'Chemistry of the adaptive m
 ind: lessons from dopamine'\n\nThe seminar will be taking place virtually.
 \n\nTo attend virtually\, register here.\n\nSpeaker: Roshan Cools\, PhD\n
 \nDonders Institute for Brain\, Cognition and Behaviour\, Radboudumc\, Dep
 artment of Psychiatry\, Nijmegen\, The Netherlands\n\nAbstract: The human 
 brain faces a variety of computational dilemmas\, including the flexibilit
 y/stability\, the speed/accuracy and the labor/leisure tradeoff. I will ar
 gue that striatal dopamine is particularly well suited to dynamically regu
 late these computational tradeoffs depending on constantly changing task d
 emands. This working hypothesis is grounded in evidence from recent studie
 s on learning\, motivation and cognitive control in human volunteers\, usi
 ng chemical PET\, psychopharmacology\, and/or fMRI. These studies also beg
 in to elucidate the mechanisms underlying the huge variability in catechol
 aminergic drug effects across different individuals and across different t
 ask contexts. For example\, I will demonstrate how effects of the most com
 monly used psychostimulant methylphenidate on learning\, Pavlovian and eff
 ortful instrumental control depend on fluctuations in current environmenta
 l volatility\, on individual differences in working memory capacity and on
  opportunity cost respectively.\n\nBio: Roshan Cools is Principal Investig
 ator at the Donders Institute for Brain\, Cognition and Behaviour and Prof
 essor of Cognitive Neuropsychiatry at the Radboud University Medical Cente
 r. She is an expert in the chemical neuromodulation of human cognition and
  motivation. She completed her undergraduate degree in Experimental Psycho
 logy at the University of Groningen\, Netherlands\, in 1998. She then move
 d to Trevor Robbins’ lab at the University of Cambridge\, UK\, for an MPhi
 l degree (1999)\, a PhD degree (2002)\, in cognitive neuroscience\, a St J
 ohn’s College Junior Research Fellowship (2002-2006) and a Royal Society D
 orothy Hodgkin Research Fellowship (2002 – 2006). She spent two post-doc y
 ears at UC Berkeley working with Mark D’Esposito from 2003\, before moving
  back to Cambridge in 2005\, where she obtained a Royal Society University
  Research Fellowship (2006 -2007). In November 2007 she returned to The Ne
 therlands\, where she is now also a member of the Royal Netherlands Academ
 y of Arts and Sciences (KNAW) and the Academia Europea. She is also a memb
 er of the (Dutch Government) Advisory Council for Science\, Technology and
  Innovation (AWTI\, since 2014).\n\n\nSupported by the generosity of the K
 illam Trusts \, The Neuro’s Killam Seminar series hosts outstanding guest 
 speakers.\n
DTSTART:20220614T200000Z
DTEND:20220614T210000Z
SUMMARY:Killam Seminar Series: Chemistry of the adaptive mind: lessons from
  dopamine
URL:/neuro/channels/event/killam-seminar-series-chemis
 try-adaptive-mind-lessons-dopamine-339772
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