Reggie Charles Hamdy
- Professor, Surgery
- Head, Division of Paediatric Orthopaedics, Department of Paediatric Surgery
- Chief of Staff, Shriners Hospital for Children, Canada
- Associate Chair, Development, Department of Paediatric Surgery
MB, MSc (Ortho), FRCSC
Pediatric Othopaedic Fellowship
Brown University
Providence, Rhode Island
1991 鈥� 1992
Pediatric Orthopaedic Fellowship
Hospital for Sick Children
Toronto, Ontario, Canada
1990 鈥� 1991
My research interest is focused on the stimulation of bone formation in cases of distraction osteogenesis, using various animal models (rabbit and mouse). Distraction osteogenesis is a surgical technique used for the replacement of bone loss secondary to trauma, post resection of tumours and infections and also for lengthening bones in cases of limb length discrepancy. It consists of performing an osteotomy of the bone to be lengthened and application of an external fixator, followed by gradual distraction of the bone segments until the necessary length is obtained. The fixator is kept in place until the newly formed bone is consolidated. If we can accelerate the consolidation of this newly formed bone, the fixator can be removed earlier and many of the complications associated with this technique could be avoided.
I have been using various growth factors locally applied to stimulate bone formation at the lengthened site, including BMPs. Methods of assessment include histology, histomorphometry, X-Rays, DEXA, microCT, biomechanical testing, Immunohistochemistry, RT-PCR, micro-arrays. I have started to use knockout mice for various osteogenic genes to further characterize the important genes in distraction osgteogenesis.
Deformity, Correction, Limb Lengthening & Management of Children Affected with Various Neuromuscular Conditions
Reggie C. Hamdy is Professor Of Orthopaedic Surgery,鈥痑nd Director, Division of Paediatric Orthopaedics 黑料社, Montreal and Chief of Staff, Shriners Hospital for Children, Canadian Unit, Montreal. He is also Vice Chair - planning and development - Department of Paediatric Surgery, 黑料社.
His mani basic science research interests include various techniques of bone regeneration, including the use of Bone Morphogenetic Proteins and how to enhance the osteogenic activity of these factors, the use of nanotechnology to deliver siRNA and growth factors, the study of mechanotransduction using various animal models of distraction osteogenesis and the evaluation of molecular signaling in distraction osteogenesis.
His main interests in clinical research include functional outcome in cases of deformity correctiona and limb lengthening, various hip problems in children and children with arthrogryposis.
He has published鈥� over seventy peer reviewed articles, is Editor of a Monograph on the Management of limb Length Discrepancy from the AAOS (American Academy of Orthopaedic Surgeons). Co-Editor of Limb Lengthening Reconstruction Atlas frm Springer. He is the incoming President of the LLRS (Limb Lengthening and Reconstructive Society of North America). He is Prinicipal Investigator and Co-Principal Investigator on several peer reviewed grants. He is supervising several graduate students on a regular basis.