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UID:20250904T003145EDT-1878SWNsFc@132.216.98.100
DTSTAMP:20250904T043145Z
DESCRIPTION:Kidney transplantation is life saving and compared to dialysis 
 improves patient quality of life and decreases healthcare costs over time\
 , but graft longevity is compromised by immunologic rejection and inadequa
 te immunosuppression. Furthermore\, the response to treatment for T-cell m
 ediated rejection (TCMR) can be variable\, is currently not predictable by
  clinical diagnostics nor understood from a mechanistic sense\, and even p
 artial treatment failure is associated with shortened graft longevity.\n\n
 Intra-graft mechanisms of TCMR are poorly defined\, largely because canoni
 cal methods of studying T cell biology require quantities of tissue that a
 re not feasible to obtain longitudinally\, T cells in dense extracellular 
 matrix of the kidney are difficult to extract\, and relevant animal models
  are poorly replicative of chronic disease in humans. Nevertheless\, vast 
 numbers of archived longitudinal allograft biopsy samples\, with fine-grai
 ned contemporaneous clinical data\, exist in the medical record and pathol
 ogy archives. Therefore\, there is both a strong need to develop novel app
 roaches to interrogate residual diagnostic biopsy samples\, and a unique o
 pportunity to gain knowledge from materials and data already at hand\, to 
 improve patient outcomes in kidney transplantation and to further understa
 nd the behavior of T cells in human tissues.\n\nToward this\, we are devel
 oping purpose-built discovery-based assays designed for maximal efficiency
  of information return from residual small biopsy allograft samples taken 
 in the clinical course of kidney transplantation and held in pathology arc
 hives.\n
DTSTART:20191101T150000Z
DTEND:20191101T160000Z
LOCATION:Room 1034\, McIntyre Medical Building\, CA\, QC\, Montreal\, H3G 1
 Y6\, 3655 promenade Sir William Osler
SUMMARY:Seminar - Reduce\, Reuse and Recycle: Increasing information yield 
 from human tissue to improve kidney transplant outcomes
URL:/physiology/channels/event/seminar-reduce-reuse-an
 d-recycle-increasing-information-yield-human-tissue-improve-kidney-transpl
 ant-302041
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