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UID:20250904T170814EDT-6145lLE0vZ@132.216.98.100
DTSTAMP:20250904T210814Z
DESCRIPTION:\n	Cells tightly regulate microtubule dynamics throughout differ
 ent stages of the cell cycle. During mitosis microtubule growth rates incr
 ease by 50%\, while nucleation rates increase about 7-fold. This change of
  microtubule dynamics is essential for the formation and function of the m
 itotic spindle\, and its misregulation can lead to aneuploidy and cancer. 
 Using CRISPR knockout cells as well as in-vitro reconstitution assays we s
 how that the mitotic spindle protein Cytoskeleton-Associated Protein 2 (CK
 AP2) has a strong effect on nucleation of microtubules by lowering the cri
 tical tubulin concentration 100-fold. CKAP2 increases the apparent rate co
 nstant ka of microtubule growth by 50-fold. Our results identify CKAP2 as 
 the most potent microtubule growth factor to date. These finding help expl
 ain CKAP2s role as an important spindle protein\, proliferation marker\, a
 nd oncogene.\n\nThis seminar will be held online via Zoom.\n
DTSTART:20200417T150000Z
DTEND:20200417T160000Z
LOCATION:via Zoom\, McIntyre Medical Building\, CA\, QC\, Montreal\, H3G 1Y
 6\, 3655 promenade Sir William Osler
SUMMARY:Online seminar: CKAP2 is the most potent microtubule growth factor 
 in mitotic spindles
URL:/physiology/channels/event/online-seminar-ckap2-mo
 st-potent-microtubule-growth-factor-mitotic-spindles-321080
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