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BEGIN:VEVENT
UID:20250904T075422EDT-9950WC71fP@132.216.98.100
DTSTAMP:20250904T115422Z
DESCRIPTION:Genetic changes are a hallmark of cancer but are particularly p
 rominent in solid tumors compared to liquid tumors. Moreover\, tumors that
  arise in stiffer tissues show more genetic changes than tumors in softer 
 tissues. We developed a method to visualize a common type of genetic chang
 e in live cells through application of gene editing\, and we use the engin
 eered cells to assess a ‘mechano-genetics’ mechanism for the observed scal
 ing of cancer mutations. Such changes are in principle detectable by the i
 mmune system\, but checkpoint ligands on cancer cells can passivate attack
  by immune cells – including a phagocytic synapse. We describe disruption 
 of this macrophage checkpoint that\, in a combination treatment strategy\,
  initiates a ‘phagocytic feedback’ loop. In a widely used but challenging 
 pre-clinical model\, the approach generates durable cures and anti-tumor i
 mmunity.\n\nThis seminar will be given online via Zoom. Details in attache
 d poster.\n
DTSTART:20210115T160000Z
DTEND:20210115T170000Z
SUMMARY:Online Seminar - Convergent science approaches to Solid Tumors: Fro
 m Mechano-Genetic Variation to Phagocytic Synapses
URL:/physiology/channels/event/online-seminar-converge
 nt-science-approaches-solid-tumors-mechano-genetic-variation-phagocytic-32
 7476
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