BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//132.216.98.100//NONSGML kigkonsult.se iCalcreator 2.20.4//
BEGIN:VEVENT
UID:20250904T032142EDT-7038mDxxxZ@132.216.98.100
DTSTAMP:20250904T072142Z
DESCRIPTION:Cells are truly the ultimate “smart-material” fine-tuning their
  mechanical properties to match the mechanical demands of their environmen
 ts. Such plasticity of cell mechanics relies heavily on the spatiotemporal
  regulation of the actomyosin cytoskeleton\, and plays a protective role s
 afeguarding cells against mechanical damage. Yet\, mechanisms of the adapt
 ive changes in cell mechanics remain elusive. In this presentation\, I wil
 l report a new mechanism whereby mechanically activated actin elongation f
 actor mDia1 controls the dynamics of actin polymerization at focal adhesio
 ns\, force bearing linkages between the actin cytoskeleton and extracellul
 ar matrix. By combining live-cell imaging with mathematical modelling\, we
  show that actin polymerization at focal adhesions exhibits pulsatile dyna
 mics where the spikes of mDia1 activity are triggered by cell-generated co
 ntractile forces. We show that suppression of mDia1-mediated actin polymer
 ization at focal adhesions results in two-fold increase in mechanical tens
 ion on the stress fibers. This elevated tension leads to an increased freq
 uency of spontaneous stress fiber damage and decreased efficiency of zyxin
 -mediated stress fiber repair. We conclude that tension-controlled actin p
 olymerization at focal adhesions acts as a safety valve dampening excessiv
 e mechanical tension on the actin cytoskeleton and safeguarding stress fib
 ers against mechanical damage.\n\nThis seminar will be given online via Zo
 om. Details in attached poster.\n
DTSTART:20210226T160000Z
DTEND:20210226T170000Z
SUMMARY:Online Seminar - Activation of Actin Elongation Factor Dia1 by Mech
 anical Force Protects the Cytoskeleton from Damage and Facilitates Stress 
 Fiber Repair
URL:/physiology/channels/event/online-seminar-activati
 on-actin-elongation-factor-dia1-mechanical-force-protects-cytoskeleton-dam
 age-328178
END:VEVENT
END:VCALENDAR