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UID:20250828T202636EDT-0386SbwtxS@132.216.98.100
DTSTAMP:20250829T002636Z
DESCRIPTION: \n\nIn this talk\, I will discuss the use of precision genome 
 editing to advance our study of protein and gene function\, alongside its 
 translational application to characterize human genetic variation and to d
 esign exosite-directed drugs. In particular\, I will present my research o
 n 53BP1-mediated p53 regulation to exemplify how base editing screens incr
 ease the resolution and output of phenotype-genotype analyses. Also\, I wi
 ll highlight the current utility and future potential of a versatile preci
 sion genome editing platform for high throughput functionalization of vari
 ants of uncertain significance associated with human disorders. Finally\, 
 I will outline the application of base editing screens to drug development
 \, focusing on the relevance of deep mutagenesis analyses combined with st
 ructural data to pinpoint exosites of druggable potential.\n\nThis seminar
  will take place both in-person and online\, Details in attached poster\n
DTSTART:20230127T160000Z
DTEND:20230127T170000Z
LOCATION:Room 1034\, McIntyre Medical Building\, CA\, QC\, Montreal\, H3G 1
 Y6\, 3655 promenade Sir William Osler
SUMMARY:Physiology Seminar: Precision genome editing to study protein funct
 ion\, genetic variation and drug development
URL:/physiology/channels/event/physiology-seminar-prec
 ision-genome-editing-study-protein-function-genetic-variation-and-drug-345
 145
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