BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//132.216.98.100//NONSGML kigkonsult.se iCalcreator 2.20.4//
BEGIN:VEVENT
UID:20250828T163526EDT-308094daSs@132.216.98.100
DTSTAMP:20250828T203526Z
DESCRIPTION: \n\nDr. Butovsky’s major scientific interest is to understand 
 the biology of resident microglia and peripheral inflammatory monocytes in
  homeostasis and neurodegenerative conditions. During his Ph.D. studies at
  the Weizmann Institute of Science\, he investigated the role of microglia
  in regulating the Aβ plaque deposition in AD models and the role of micro
 glia in neurogenesis. His laboratory identified subpopulations of microgli
 a and demonstrated how microglia can be both beneficial and detrimental in
  the context of neurodegeneration and is elucidating the relationship of m
 icroglia to CNS diseases including AD\, MS\, and ALS. The above-mentioned 
 findings prompted him to investigate further the role of innate immunity i
 n AD. His laboratory recently identified a new role of APOE in microglia r
 egulation in neurodegenerative diseases which has been widely recognized i
 n the field. This has led to the investigation of APOE in microglia regula
 tion during disease progression in AD and TAU mice\, following the establi
 shment of a consortium funded by Cure Alzheimer’s Fund\, of which he is a 
 member. This collaboration led to the identification of the negative role 
 of APOE4 in the regulation of microglia-astrocyte interactions in AD. Thes
 e findings led his laboratory to study how other AD risk genes expressed i
 n microglia impair MGnD-astrocyte crosstalk\, promoting the initiation and
  progression of the disease. With the new knowledge gained\, he hopes to a
 ddress fundamental questions of the role of microglia in neurodegenerative
  conditions and apply this knowledge towards the development of novel immu
 ne-based targeting therapies for AD.\n\nThis seminar will take place both 
 in-person and online. Details in attached poster\n
DTSTART:20230217T160000Z
DTEND:20230217T170000Z
LOCATION:room 1034\, McIntyre Medical Building\, CA\, QC\, Montreal\, H3G 1
 Y6\, 3655 promenade Sir William Osler
SUMMARY:Physiology Seminar: APOE4-mediated microglial regulation has an opp
 osite effect in Glaucoma and Alzheimer’s disease
URL:/physiology/channels/event/physiology-seminar-apoe
 4-mediated-microglial-regulation-has-opposite-effect-glaucoma-and-alzheime
 rs-345875
END:VEVENT
END:VCALENDAR