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UID:20250829T161025EDT-5058v3oeH4@132.216.98.100
DTSTAMP:20250829T201025Z
DESCRIPTION: \n\nModeling how cytokine communications regulate the phenotyp
 ic variability of immune cells across spatio-temporal scales\n\nGrégoire A
 ltan-Bonnet\n\nNational Cancer Institute\, NIH\n\nCytokine-mediated commun
 ications are critical for leukocytes of the immune system to integrate the
 ir individual responses into tissue-level and context-appropriate response
 s. The distance and the timing over which this communication happens in im
 mune tissues and tumors must be highly variable (to match varied pathogeni
 c onslaughts) yet tightly regulated (to avoid autoimmune mistakes).\n\nWe 
 will present recent theoretical and experimental results demonstrating how
  a simple diffusion-consumption mechanism quantitatively describes the spa
 tial spread of cytokines\; this mechanism explains how localized niches of
  high cytokine concentrations self-assemble in dense tissues. The volumes 
 of these cytokines niches are determined by the competition between cytoki
 ne diffusion and absorption by cells surrounding the cytokine source. In t
 urn\, the variability of niche sizes accounts for the cell-to-cell heterog
 eneity of cytokine responses that is so critical to the plasticity of immu
 ne responses.\n\nWe will also hash out how individual cells enforce tissue
 -level memory of inflammation by coordinating their response across long t
 imescales. We uncover a new mode of time integration\, whereby cancer and 
 immune cells rely on their surface phosphatidylserine to mediate the catch
  & release of inflammatory cytokines. This mode of cytokine communications
  converts transient exposure to cytokines into long-term inflammation.\n\n
 To conclude\, we will discuss how quantitative approaches bring a mechanis
 tic understanding to address fundamental issues in immunology and to desig
 n better immunotherapies.\n
DTSTART:20180215T170000Z
DTEND:20180215T180000Z
LOCATION:908\, McIntyre Medical Building\, CA\, QC\, Montreal\, H3G 1Y6\, 3
 655 promenade Sir William Osler
SUMMARY:QLS Featured Seminar Series - Dr. Gregoire Altan-Bonnet
URL:/qls/channels/event/qls-featured-seminar-series-dr
 -gregoire-altan-bonnet-285263
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