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UID:20250703T233704EDT-0209eOZvHC@132.216.98.100
DTSTAMP:20250704T033704Z
DESCRIPTION:High-resolution lineage tracking reveals coupling between intra
 -species and community-level population dynamics during bacterial coloniza
 tion of the mouse gut\n\nAdrian Serohijos\, Université de Montréal\n	Tues
 day December 1\, 12-1pm\n	Zoom Link: https:/mcgill.zoom.us/j/91589192037\n
 \nAbstract: Evolution is a unifying theme in the urgent medical and public
  health problems we face today including cancer\, the rise of antibiotic r
 esistance\, and the spread of pathogens. But the ability to predict evolut
 ion remains a major challenge because it requires bridging several scales 
 of biological organization. Potential evolutionary pathways are determined
  by the cellular “fitness landscape” (the genotype-phenotype relationship)
 \, but how this landscape is explored depends on the principles of populat
 ion genetics and ecology.\n\nIn this seminar\, I will describe a chromosom
 al barcoding technique that allows simultaneous tracking of ~106 distinct 
 bacterial cell lineages in an evolving bacterial population. We used this 
 approach to study microbial populations evolving under sub-inhibitory anti
 biotic concentrations and consequently to quantify the balance between dri
 ft\, mutation\, and selection. Additionally\, I will show how the barcodin
 g technology reveals the coupling between intra-species and community-leve
 l dynamics during bacterial colonization and antibiotic treatment in mamma
 lian gut.\n
DTSTART:20201201T170000Z
DTEND:20201201T180000Z
LOCATION:CA\, QC
SUMMARY:QLS Seminar Series- Adrian Serohijos
URL:/qls/channels/event/qls-seminar-series-adrian-sero
 hijos-326295
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